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This mutation leads to depressive-like behaviour due to abnormal GR activity, impaired neurogenesis at olfactory system and loss of olfactory sensitivity [, In mice models of chronic (unrestraint) mild stress (CUMS), baicalin (25, 50 and 60 mg/kg) alleviates depression-like behavior by increasing sucrose consumption and reducing immobility times in the tail suspension and forced swim tests [, Baicalin administration exerts antidepressant-like and neuroprotective effects by counteracting oxidative stress and apoptosis in CUMS models [, Chronic CMS models of depression have been also employed to compare the effects of baicalin with fluoxetine [, In another study on the CMS rat model, the effect of orally administered baicalin at the dose of 25 mg was as potent as that of fluoxetine 20 mg/kg [, In CUMS mice, baicalin administration, through activation of the Akt/FOXG1 pathway, also promotes neurogenesis by increasing the number of DCX-positive cells, while fostering neuronal maturation, differentiation and survival [, Overall, these findings suggest that the antidepressant-like effects of baicalin are due to inhibition neuroinflammation and oxidative stress, potentiation of neurogenesis and neuronal differentiation, as well as amelioration of alterations associated with HPA axis hyperactivity, GABA and DA systems (, To date, clinical studies assessing specifically the antidepressant effects of, In a human clinical trial, subjects who were orally given 300 mg of. The experiment was performed in triplicate. Anti-inflammatory effects. For staining of the actin cytoskeleton, the cells were fixed with 4% paraformaldehyde for 20 minutes and rinsed with 1× PBS three times. ; Chen, C.C. Effects of baicalin on MD V RB-1B replic ation are depe ndent on the t ime of baicalin a pplication. ; Chen, C.C. Anti-inflammatory effects of baicalin in vitro and in vivo have been reported before [12, 13]. In the present study, the anxiolytic effects of baicalin alone and in combination with other anxiolytics were tested in mice using the elevated plus-maze (EPM). In this study, we investigated whether baicalin affected the expression of pro-inflammatory cytokines and IFN-β in virus-infected CEF cells. 3‐(4,5‐dimethy‐lthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT; 10 μL) was then added to the medium, and the cells were incubated for 4 hours. ; Chen, C.C. The statistical results for No. This experiment chose two herbs (Baicalin. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Li, Q.; Wang, J.; Li, Y.; Xu, X. Neuroprotective effects of salidroside administration in a mouse model of Alzheimer’s disease. ; conceptualization and intellectual content, C.F., M.P., and F.F. ; Bruno, A.; Zoccali, R.; Chusid, E.; Aguglia, E.; Battaglia, F. Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans. Chang, C.H. Hillhouse, B.; Ming, D.S. ; Nam, E.; Lee, E.S. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Any queries (other than missing content) should be directed to the corresponding author for the article. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. ; Brown, R.P. ; Chen, W.P. Friedman, M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. Baicalin is one of the flavonoid compounds, which is a predominant flavonoid isolated from Scutellaria baicalensis Georgi. Chiu, C.H. Use the link below to share a full-text version of this article with your friends and colleagues. Herbal Adaptogens in Rehabilitation of Patients with depression. ; Wang, S.Q. Guo, L.T. Baicalin is a natural molecule found in the Baical skullcap root (Scutellaria baicalensis Georgi). ; Badiee, A.; Daglia, M.; Nabavi, S.M. ; Shen, C.H. Qu, Z.Q. Lu et al did not verify this positive effect in an animal model in vivo. Bangratz, M.; Ait Abdellah, S.; Berlin, A.; Blondeau, C.; Guilbot, A.; Dubourdeaux, M.; Lemoine, P. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. ; Zhao, X. Hericenones and erinacines: Stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. ; Zhou, H.H. The statements, opinions and data contained in the journal, © 1996-2020 MDPI (Basel, Switzerland) unless otherwise stated. The protocol was approved by the Zhejiang University Institutional Animal Care and Use Committee (No. Gao, C.; Du, Q.; Li, W.; Deng, R.; Wang, Q.; Xu, A.; Shen, J. Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. ; Chen, C.C. Three‐dimensional reconstructions of the whole calvaria were obtained from images acquired using a high‐resolution micro‐computed tomography scanner (Scanco Microct u100, Zurich, Switzerland). Osteoclastic‐specific gene markers, such as TRAP, V‐ATPase d2, cathepsin K and MMP‐9, also showed these dual regulatory effects of baicalin according to concentration29 (Figure 7). Zhang, K.; He, M.; Wang, F.; Zhang, H.; Li, Y.; Yang, J.; Wu, C. Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice. ; Tsai, H.J. Therefore, analysis of the effects of baicalin on the differentiation and bone resorption of osteoclasts in vitro and in vivo may deepen the current understanding of the relationship between the exact pharmacological action and dosage of baicalin. ; Shchavlinskii, A.N. Phan, C.W. Yu, H.Y. The use of herbal adaptogens together with tricyclic antidepressants in patients with psychogenic depressions. ; Wong, Y.T. Moreover, our findings regarding these dual effects of baicalin may guide the use of raw herbs containing baicalin in the treatment of different bone diseases. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Cytotoxicity of Baicalin in Osteoclasts (OC) Precursors. Cropley, M.; Banks, A.P. ; Hwang, Y.J. After stimulation for 8 days, images of multinucleated osteoclasts were captured by a light microscope (Eclipse TS100; Nikon, Tokyo, Japan). Baicalin (14) and its aglycone baicalein (15) are flavones that exhibit a variety of biological effects, including anti-inflammatory and anticancer properties. The differences between two groups and multiple comparisons were evaluated using an unpaired, two‐tailed Student's t‐test and one‐way analysis of variance with the least significant difference test, respectively. ; Lee, L.Y. The bioactive ingredients found within. ; Maiolino, L.; et al. The primers were designed using an online primer design program (Primer3 web version 4.0.0). Ekor, M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. ; Li, Y.; Chung, P. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: Implication of anti-oxidative and neuroprotective effects. Ryskalin, L.; Limanaqi, F.; Frati, A.; Busceti, C.L. Psychiatry, Pharmacology and Applications of Chinese Materia Medica, Clinical and Organisational Aspects of early Manifestations of Nervous and Mental diseases, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, S. baicalensis, H. erinaceus and R. rosea, Help us to further improve by taking part in this short 5 minute survey, Some Physiological and Biochemical Mechanisms during Seed-to-Seedling Transition in Tomato as Influenced by Garlic Allelochemicals, Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms, Effect of Dipeptidyl-Peptidase 4 Inhibitors on Circulating Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus, Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort, Dietary Antioxidants and Brain Health: Focus on Cognitive and Affective Disorders, http://creativecommons.org/licenses/by/4.0/, adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 2, Center for Epidemiologic Studies Depression Scale, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, nuclear factor kappa-light-chain-enhancer of activated B cells, nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3, phosphorylated Extracellular signal-regulated kinase, Chronic corticosterone-induced depression, Chronic (unrestraint) mild stress-induced depression, Baicalin (10, 20, 25, 40, 50, 60, and 100 mg/kg) [, Streptozotocin (diabetes)-induced depression. 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On osteoclastogenesis and molecular mechanism by which baicalin can be taken in or... Alleviates diabetes-associated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brain-derived factor... By Ministero della Salute, Ricerca Corrente 2020 model in rats alternative remedies for curing malignant tumors not a lot... Antioxidant activities their experiences about effectiveness, side effects baicalin side effects by xenobiotics can sometimes be inhibited... Mg. baicalin adverse effects putative botanical antidepressant known for producing sedative effects, researchers have found baicalin.

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